Cancer patients commonly experience a number of symptoms of disease progression and the side-effects of radiation therapy and adjuvant chemotherapy, which adversely impact on their quality of life (QOL). Fatigue is one of the most common and debilitating symptom reported by cancer patients and can affect QOL more than pain.
Several recent studies have indicated that intravenous (IV) vitamin C alleviates a number of cancer- and chemotherapy-related symptoms, such as fatigue, insomnia, loss of appetite, nausea, and pain. Improvements in physical, role, cognitive, emotional, and social functioning, as well as an improvement in overall health, were also observed.
Our study suggests an acute BP-reducing effect of high-dose IVC, particularly with dosages above 30 g, and in patients with prehypertension and normal BMI. Furthermore, our study indicated a marked and clinically relevant hypertensive effect of IVB12, suggesting routine BP monitoring during i.v. therapy in clinical practice.
Intravenous Vitamin C reduced fatigue at two hours, and the effect persisted for one day. There were no significant differences in adverse events between two groups. High dose intravenous vitamin C proved to be safe and effective against fatigue in this study.
Taken together, Vitamin C shows in vivo anti-viral immune responses at the early time of infection, especially against influenza virus, through increased production of IFN-α/β.
Administration of Vitamin C to CHF patients suppresses EC apoptosis in vivo, which might contribute to the established functional benefit of Vitamin C supplementation on endothelial function.
If similar effects are observed in patients with atherosclerosis or risk factors, Vitamin C supplementation might prove an effective therapy in cardiovascular disease.
Vitamin E and C supplementation had a modest anti-inflammatory effect in chronic degenerative AS.
Plasma F2IsoP concentrations of subjects in the vitamin C and mixture groups decreased significantly by 17.2 pmol/l (P = 0.0105) and 19.2 pmol/l (P = 0.0083) when compared with the placebo group (11.4% and 12.7%, respectively). Daily AO supplementation (especially with vitamin C) decreases this oxidative stress biomarker in passive smokers.
The results suggest that dietary supplementation with Vitamins E and C benefits asthmatic adults who are exposed to air pollutants.
Overall, inadequate intake and status of [some] vitamins and minerals may lead to suppressed immunity, which predisposes to infections and aggravates malnutrition.
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